全球首个基因编辑猴模型 一站式服务平台
The World's First Gene-edited Monkey Model One-stop Service Platform
神桥生物 · 初心·使命·愿景
NeuroBridge - Vision · Mission · Aspiration
广州神桥生物科技有限公司成立于2023年9月，是一家专注非人灵长类动物 (NHP)精准基因编辑疾病模型开发应用与转化的平台。
Founded in September 2023, Guangzhou NeuroBridge Biotechnology Co., Ltd. is a platform dedicated to the development, application and transformation of precision gene-edited disease models for non-human primates (NHPs).
深耕非人灵长类基因编辑领域，以猴等非人灵长类动物为核心载体，链接科研与临床需求，用精准模型搭建生命健康的探索之桥，用专业服务赋能医学创新突破。
Deeply engaged in the field of non-human primate gene editing, we take monkeys and other non-human primates as the core carrier, connect scientific research and clinical needs, build a bridge for exploring life and health with precise models, and empower medical innovation breakthroughs with professional services.
初心
Original Aspiration
源于对生命的敬与对医学困境的深切感知，立志打破灵长类基因编辑模型领域的技术壁垒与应用瓶颈。以"让科研更高效、让诊疗有突破"为初心，打造一站式服务平台，为无数受疾病困扰的家庭带去希望。
Rooted in respect for life and deep understanding of medical dilemmas, we aim to break the technical barriers and application bottlenecks in the field of primate gene-edited models. With the original aspiration of "Making scientific research more efficient and enabling breakthroughs in diagnosis and treatment", we build a one-stop service platform to bring hope to countless families affected by diseases.
使命
Mission
聚焦基因编辑猴模型的研发、制备与全链条服务，搭建科研与临床的桥梁，赋能医学创新，守护人类健康。提供标准化、定制化的基因编辑猴模型及配套技术服务，加速科研成果向临床应用转化。
Focus on the R&D, preparation and full-chain services of gene-edited monkey models, build a bridge between scientific research and clinical practice, empower medical innovation, and protect human health. Provide standardized and customized gene-edited monkey models and supporting technical services to accelerate the transformation of scientific research achievements into clinical applications.
愿景
Vision
成为全球灵长类基因编辑模型领域的引领者与最受信赖的合作伙伴，助力人类攻克重大疾病难题，最终实现"尝尽世间药，只为人健康"的美好愿景。
To become a global leader and the most trusted partner in the field of primate gene-edited models, help humanity overcome major disease challenges, and ultimately realize the beautiful vision of "All For Your Health".
专业的技术团队
Professional Technical Team
- 创始团队具有10余年的大动物疾病模型构建、应用和转化经验
- 主持多项国家级、省部级科研项目和人才项目（国家优青、广东省珠江人才计划等）
- 在Cell、Cell stem Cell等国际Top期刊发表30多篇高水平研究论文
- 可提供个性化疾病模型构建和应用方案，确保实验结果准确可靠
- The founding team has more than 10 years of experience in the construction, application and transformation of large animal disease models
- Hosted a number of national and provincial scientific research projects and talent programs (National Excellent Young Scholars, Guangdong Pearl River Talent Program, etc.)
- Published more than 30 high-level research papers in international top journals such as Cell and Cell Stem Cell
- Can provide personalized disease model construction and application solutions to ensure accurate and reliable experimental results
发展规划
Development Plan
- 3-5年内建成世界首个国际化基因编辑猴模型服务平台，建立数十种基因编辑动物猴模型
- 5-10年建成国际化基因编辑猴模型转化应用平台，建立数百种基因编辑猴模型群体
- 为更多生物医药领域科学家和工业用户更好赋能
- Build the world's first international gene-edited monkey model service platform within 3-5 years, establishing dozens of gene-edited monkey models
- Build an international transformation and application platform for gene-edited monkey models within 5-10 years, establishing hundreds of gene-edited monkey model populations
- Better empower more scientists and industrial users in the biomedical field
核心优势
Core Advantages
- 平台制备模型猴，技术壁垒、时间成本低
- 用猴成本低，超高性价比赋能科学家
- 交叉学科/项目融合，促进多方合作
- 多维度研究疾病，赋能基础科研原始创新
- Platform-prepared model monkeys with low technical barriers and time costs
- Low cost of monkey usage, ultra-high cost performance to empower scientists
- Interdisciplinary/project integration to promote multi-party cooperation
- Multi-dimensional disease research to empower original innovation in basic scientific research
基因编辑猴模型制备流程
Gene-edited Monkey Model Preparation Process
- Transgene 转基因操作
- Gene targeting 基因靶向编辑
- ICSI & CRISPR/CAS9 精卵胞质内注射+基因编辑
- 脑立体定位注射猴实验
- AAV病毒介导的基因递送
- Transgene Manipulation
- Gene Targeting Editing
- ICSI & CRISPR/CAS9 (Intracytoplasmic Sperm Injection + Gene Editing)
- Stereotactic Injection in Monkey Brain
- AAV Virus-mediated Gene Delivery
核心产品与服务体系
Core Products and Service System
疾病模型定制
Disease Model Customization
- 神经退行性疾病(AD,PD,ALS)
- 神经发育性疾病(自闭症)
- 罕见疾病模型
- 肿瘤模型(SSTR2、EGFR等)
- 其他定制化疾病模型
- Neurodegenerative Diseases (AD, PD, ALS)
- Neurodevelopmental Diseases (Autism)
- Rare Disease Models
- Tumor Models (SSTR2, EGFR, etc.)
- Other Customized Disease Models
药效与技术评价
Efficacy and Technology Evaluation
- 新药管线药效评价
- 中药提取物效果评价
- 基因治疗技术开发与评价
- 干细胞治疗技术开发与评价
- 新型医疗器械开发与评价
- New Drug Pipeline Efficacy Evaluation
- Chinese Medicine Extract Efficacy Evaluation
- Gene Therapy Technology Development & Evaluation
- Stem Cell Therapy Technology Development & Evaluation
- New Medical Device Development & Evaluation
特色技术服务
Specialized Technical Services
- 疾病模型猴脑机接口开发
- 一站式模型构建全流程服务
- 个性化实验设计与数据分析
- Disease Model Monkey Brain-Computer Interface Development
- One-stop Model Construction Full-process Service
- Personalized Experimental Design & Data Analysis
已构建核心模型
Established Core Models
- Tau转基因阿尔兹海默病猴模型
- SHANK3基因编辑自闭症猴模型
- CHD8基因编辑自闭症猴模型
- PINK1基因敲除帕金森病猴模型
- Parkin基因敲除帕金森病猴模型
- IL2RG,RAG1敲除免疫缺陷猴模型
- Tau Transgenic Alzheimer's Disease Monkey Model
- SHANK3 Gene-edited Autism Monkey Model
- CHD8 Gene-edited Autism Monkey Model
- PINK1 Knockout Parkinson's Disease Monkey Model
- Parkin Knockout Parkinson's Disease Monkey Model
- IL2RG, RAG1 Knockout Immunodeficiency Monkey Model
全维度检测分析技术
Comprehensive Detection and Analysis Technologies
- 分子生物学分析
- 分子影像学分析
- 生物标志物分析
- 病理学分析
- 单细胞学分析
- 转录组与蛋白组联合分析
- 行为学分析
- Molecular Biology Analysis
- Molecular Imaging Analysis
- Biomarker Analysis
- Pathological Analysis
- Single-cell Analysis
- Transcriptome & Proteome Joint Analysis
- Behavioral Analysis
模型核心行为特征
Core Behavioral Characteristics of Models
- SHANK KO猴：严重社交障碍
- Tau转基因猴：记忆认知缺陷
- 自闭症模型猴：重复性行为
- PD模型猴：典型帕金森运动障碍
- AD模型猴：阿尔兹海默典型症状
- SHANK KO Monkeys: Severe Social Disorders
- Tau Transgenic Monkeys: Memory & Cognitive Deficits
- Autism Model Monkeys: Repetitive Behaviors
- PD Model Monkeys: Typical Parkinson's Motor Disorders
- AD Model Monkeys: Typical Alzheimer's Symptoms
铸神经科学之桥 通生命健康大道
Building a Bridge for Neuroscience, Paving the Way for Life and Health
建立资源样本库
Establish Resource Sample Library
提高模型猴利用率，整合科研资源，全面立体研究疾病进程机体变化
Improve model monkey utilization, integrate scientific research resources, and comprehensively study the body changes during disease progression
赋能科研机构
Empower Research Institutions
为高校、医院等提供成规模模型，促进基础科研突破，赋能原始创新
Provide large-scale models for universities and hospitals, promote basic scientific research breakthroughs, and empower original innovation
助力工业客户
Support Industrial Clients
为药企、CRO等精准做临床前药物评价，结合先进技术提高评估准确性，促进新药上市
Provide accurate preclinical drug evaluation for pharmaceutical companies and CROs, improve evaluation accuracy with advanced technologies, and promote new drug launch
核心合作机构
Core Cooperation Institutions
